As at 31 December 2017, the Company is aware of the following holdings of 3% or more of the voting rights in its shares.
|Aberforth Partners LLP||16.07%||52,797,322|
|Canaccord Genuity Group Inc**||10.1558%||33,479,512|
|J O Hambro Capital Management Limited||6.10%||20,030,402|
|The Wellcome Trust Limited as a Trustee of The Wellcome Trust||5.0815%||16,683,109|
|Kabouter Management LLC||5.39%||17,753,402|
|Miton Group plc||5.0%||16,490,492|
* Percentages are based on date of notification as opposed to current issued share capital figure.
** Previously Hargreave Hale.